Research on PPR Treatment with Ivermectin in Sheep and Goat
PPR Treatment with Ivermectin. PPR in goat and PPR in Sheep is a disease that also exists in other animals. In fact, it is Peste Des Petitis Ruminants. Furthermore, PPR symptoms include fever, pneumonia, secretion from eyes and nose, and inflammation of intestines. Besides this, mortality of this disease is 80%. Moreover, it is a highly important disease due to its economic importance for livestock. UVAS conducted a research on this disease. Ivermectin for PPR Treatment shows antiviral potential. Ivermectin antiviral effects gave the positive Results. Dr. Saba Afzal conducted this PPR research at Institute of Microbiology of UVAS under the supervision of Dr. Sohail Raza.
Details of PPR in Sheep and Goats
کیرتھر پارک کے آبیکس میں پی پی آر کی تصدیق، قربان علی خشک کی ڈان کیلئے خصوصی خبر
ڈائریکٹر جنرل نیشنل ویٹرنری لیبارٹری کا جابہ لائیوسٹاک ریسرچ سنٹر کا دورہ
Ivermectin is effective in PPR treatment, a disease of sheep and goats. Research by Dr. Saba Afzal under the supervision of Dr. Sohail Raza at the Microbiology Institute of the Veterinary University Lahore.
The use of Ivermectin has been shown to be very effective and positive for the treatment of PPR, a dangerous and fatal disease of sheep and goats (also known as ‘goat plague’ or ‘kata’ disease).
Important results of the research on PPR Treatment
During laboratory tests, when the virus was allowed to grow in cell culture (VERO Cells) and at the same time, a specific concentration of ivermectin was added, the drug stopped the growth of the virus. According to the research, when ivermectin, there is a clear decrease in the titer of the virus by 2 logs.
Dr. Saba Afzal Says that adding ivermectin at the time of virus entry into the cell has been found to be more effective than adding it after the virus enters the cell.
Symptoms of PPR and Economic Loss
Animals suffering from this disease face symptoms such as high fever, watery and sticky discharge from the eyes and nose, inflammation of the intestines and lungs, and pneumonia. This disease causes an annual economic loss of 1.45 to 2.1 billion US dollars worldwide, which has the greatest impact on poor and small farmers. There are more than 37 different types of goats in Pakistan and this disease is a major challenge for the livestock sector.
Global targets and vaccine issues Global target:
The Food and Agriculture Organization (FAO) and the World Organisation for Animal Health (WOAH/OIE) have set a target of complete eradication of PPR from the world by the year 2030. There are some problems associated with the current vaccines against this disease (such as Nigeria 75/1), including the problems of their not being “thermo-stable” (effective in extreme heat).
Efficacy of ivermectin against other viruses:
Ivermectin has been found to be effective not only against this disease, but also against several other DNA and RNA viruses such as HIV, Dengue, Flavivirus, Bovine Herpes Virus-1 and most importantly SARS-CoV-2 (coronavirus).
Dr. Sohail Raza says that since this is the first study of its kind worldwide in which ivermectin is effective against the PPR virus It has been found, so it is hoped that this will be a very important step towards the global eradication of PPR. Now, in the next phase of this research, further research is underway at the university to study the effects of the drug in living organisms (in-vivo).
